Cross-reactive CD4 <sup>+</sup> T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

DOI Web Site Web Site 被引用文献3件
  • Lucie Loyal
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Julian Braun
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Larissa Henze
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Beate Kruse
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Manuela Dingeldey
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Ulf Reimer
    JPT Peptide Technologies GmbH, Berlin, Germany.
  • Florian Kern
    JPT Peptide Technologies GmbH, Berlin, Germany.
  • Tatjana Schwarz
    Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Maike Mangold
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Clara Unger
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Friederike Dörfler
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Shirin Kadler
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Jennifer Rosowski
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Kübrah Gürcan
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Zehra Uyar-Aydin
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Marco Frentsch
    Department of Hematology, Oncology and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Florian Kurth
    Department of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Karsten Schnatbaum
    JPT Peptide Technologies GmbH, Berlin, Germany.
  • Maren Eckey
    JPT Peptide Technologies GmbH, Berlin, Germany.
  • Stefan Hippenstiel
    Department of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Andreas Hocke
    Department of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Marcel A. Müller
    Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt – Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Birgit Sawitzki
    Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Stefan Miltenyi
    Miltenyi Biotec GmbH, Bergisch-Gladbach, Germany.
  • Friedemann Paul
    Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Marcus A. Mall
    Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Holger Wenschuh
    JPT Peptide Technologies GmbH, Berlin, Germany.
  • Sebastian Voigt
    Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.
  • Christian Drosten
    Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt – Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Roland Lauster
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Nils Lachman
    Institute for Transfusion Medicine, Tissue Typing Laboratory, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Leif-Erik Sander
    Department of Infectious Diseases and Respiratory Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Victor M. Corman
    Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt – Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Jobst Röhmel
    Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Lil Meyer-Arndt
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Andreas Thiel
    Si-M/“Der Simulierte Mensch,” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin, Berlin, Germany.
  • Claudia Giesecke-Thiel
    Max Planck Institute for Molecular Genetics, Berlin, Germany.

説明

<jats:title>Cross-reactive T cells aid in the fight</jats:title> <jats:p> There is mounting evidence that immunological memory after infection with seasonal human coronaviruses (hCoVs) contributes to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Loyal <jats:italic>et al</jats:italic> . identified a universal immunodominant coronavirus peptide found within the fusion peptide domain of coronavirus spike protein. This peptide is recognized by CD4 <jats:sup>+</jats:sup> T cells in 20% of unexposed individuals, more than 50% of SARS-CoV-2 convalescents, and 97% of subjects treated with the Pfizer–BioNTech COVID-19 vaccine. Although ubiquitous, these coronavirus-reactive T cells decreased with age, which may explain in part the increased susceptibility of elderly people to COVID-19. —STS </jats:p>

収録刊行物

  • Science

    Science 374 (6564), eabh1823-, 2021-10-08

    American Association for the Advancement of Science (AAAS)

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