Tissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum
-
- Sarah Forrester
- York Biomedical Research Institute, Department of Biology, University of York, York, England, United Kingdom
-
- Amy Goundry
- York Biomedical Research Institute, Department of Biology, University of York, York, England, United Kingdom
-
- Bruna Torres Dias
- Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
-
- Thyago Leal-Calvo
- Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil
-
- Milton Ozório Moraes
- Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil
-
- Paul M. Kaye
- York Biomedical Research Institute, Hull York Medical School, University of York, York, England, United Kingdom
-
- Jeremy C. Mottram
- York Biomedical Research Institute, Department of Biology, University of York, York, England, United Kingdom
-
- Ana Paula C. A. Lima
- Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
-
- Tim Downing
- editor
抄録
<jats:p> Visceral leishmaniasis (VL) is caused by two species of <jats:italic>Leishmania</jats:italic> parasites, <jats:named-content content-type="genus-species">L. donovani</jats:named-content> in the Old World and <jats:named-content content-type="genus-species">L. infantum</jats:named-content> in the New World and countries bordering the Mediterranean. Although cardinal features such as hepato-splenomegaly and alterations in blood and immune function are evident, clinical presentation may vary by geography, with for example severe bleeding often associated with VL in Brazil. </jats:p>
収録刊行物
-
- Microbiology Spectrum
-
Microbiology Spectrum 10 (2), 2022-04-27
American Society for Microbiology