Immunomodulatory effects of curcumin in systemic autoimmune diseases

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  • Sajjad Chamani
    Medical Toxicology and Drug Abuse Research Center (MTDRC) Birjand University of Medical Sciences (BUMS) Birjand Iran
  • Maryam Moossavi
    Department of Molecular Medicine Birjand University of Medical Sciences Birjand Iran
  • Ali Naghizadeh
    Medical Toxicology and Drug Abuse Research Center (MTDRC) Birjand University of Medical Sciences (BUMS) Birjand Iran
  • Mitra Abbasifard
    Immunology of Infectious Diseases Research Center Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences Rafsanjan Iran
  • Muhammed Majeed
    Department of Pharmaceutics School of Pharmaceutical Education and Research, Jamia Hamdard New Delhi India
  • Thomas P. Johnston
    Division of Pharmacology and Pharmaceutical Sciences School of Pharmacy, University of Missouri‐Kansas City Kansas City Missouri USA
  • Amirhossein Sahebkar
    Applied Biomedical Research Center Mashhad University of Medical Sciences Mashhad Iran

Abstract

<jats:title>Abstract</jats:title><jats:p>Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto‐antigen outbreak, inflammation, and multi‐organ impairment is observed in these disorders. The immune system is an essential complex network of cells and chemical mediators which defends the organism's integrity against foreign microorganisms, and its precise operation and stability are compulsory to avoid a wide range of medical complications. Curcumin is a phenolic ingredient extracted from turmeric and belongs to the Zingiberaceae, or ginger family. Curcumin has multiple functions, such as inhibiting inflammation, oxidative stress, tumor cell proliferation, cell death, and infection. Nevertheless, the immunomodulatory influence of curcumin on immunological reactions/processes remains mostly unknown. In the present narrative review, we sought to provide current information concerning the preclinical and clinical uses of curcumin in systemic autoimmune diseases.</jats:p>

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