Brain age in mood and psychotic disorders: a systematic review and meta‐analysis
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- Pedro L. Ballester
- Neuroscience Graduate Program McMaster University Hamilton Ontario Canada
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- Maria T. Romano
- Integrated Science Undergraduate Program McMaster University Hamilton Ontario Canada
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- Taiane de Azevedo Cardoso
- Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton Ontario Canada
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- Stefanie Hassel
- Mathison Centre for Mental Health Research and Education Cumming School of Medicine University of Calgary Calgary Alberta Canada
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- Stephen C. Strother
- Rotman Research Institute Baycrest Toronto Ontario Canada
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- Sidney H. Kennedy
- Centre for Depression and Suicide Studies, and Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto Ontario Canada
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- Benicio N. Frey
- Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton Ontario Canada
Description
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate whether accelerated brain aging occurs in individuals with mood or psychotic disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A systematic review following PRISMA guidelines was conducted. A meta‐analysis was then performed to assess neuroimaging‐derived brain age gap in three independent groups: (1) schizophrenia and first‐episode psychosis, (2) major depressive disorder, and (3) bipolar disorder.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 18 papers were included. The random‐effects model meta‐analysis showed a significantly increased neuroimaging‐derived brain age gap relative to age‐matched controls for the three major psychiatric disorders, with schizophrenia (3.08; 95%CI [2.32; 3.85]; <jats:italic>p</jats:italic> < 0.01) presenting the largest effect, followed by bipolar disorder (1.93; [0.53; 3.34]; <jats:italic>p</jats:italic> < 0.01) and major depressive disorder (1.12; [0.41; 1.83]; <jats:italic>p</jats:italic> < 0.01). The brain age gap was larger in older compared to younger individuals.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Individuals with mood and psychotic disorders may undergo a process of accelerated brain aging reflected in patterns captured by neuroimaging data. The brain age gap tends to be more pronounced in older individuals, indicating a possible cumulative biological effect of illness burden.</jats:p></jats:sec>
Journal
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- Acta Psychiatrica Scandinavica
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Acta Psychiatrica Scandinavica 145 (1), 42-55, 2021-09-21
Wiley
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Details 詳細情報について
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- CRID
- 1360298761838545024
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- ISSN
- 16000447
- 0001690X
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- Data Source
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- Crossref