Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy <i>via</i> a thermosensitive liposome system to stimulate tumor-specific immunological response

  • Jie Yu
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Xidong He
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Zigui Wang
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Yupeng Wang
    Department of Pharmacy, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan 528300, P. R. China
  • Sha Liu
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Xiaoyuan Li
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Yubin Huang
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

説明

<jats:p>The combination of ICB and ICD induced by PTT and OXA significantly promoted antigen presentation and infiltration of CTLs, which inhibited the relapse, regeneration, and metastasis of tumor cells.</jats:p>

収録刊行物

  • Nanoscale

    Nanoscale 13 (30), 12966-12978, 2021

    Royal Society of Chemistry (RSC)

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