Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

DOI Web Site Web Site 1 Citations
  • Philip A. Mudd
    Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Jeremy Chase Crawford
    Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA.
  • Jackson S. Turner
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
  • Aisha Souquette
    Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA.
  • Daniel Reynolds
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Diane Bender
    Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, Saint Louis, MO, USA.
  • James P. Bosanquet
    Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA.
  • Nitin J. Anand
    Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA.
  • David A. Striker
    Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA.
  • R. Scott Martin
    Department of Critical Care, Missouri Baptist Medical Center, Saint Louis, MO, USA.
  • Adrianus C. M. Boon
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Stacey L. House
    Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Kenneth E. Remy
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Richard S. Hotchkiss
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Rachel M. Presti
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Jane A. O’Halloran
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • William G. Powderly
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
  • Paul G. Thomas
    Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA.
  • Ali H. Ellebedy
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.

Abstract

<jats:p>Immunologic evaluation shows that most COVID-19 patients exhibit targeted immunosuppression compared to patients with influenza.</jats:p>

Journal

  • Science Advances

    Science Advances 6 (50), 2020-12-11

    American Association for the Advancement of Science (AAAS)

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