Temperature Sensation: From Molecular Thermosensors to Neural Circuits and Coding Principles
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- Rui Xiao
- Department of Aging and Geriatric Research, Institute on Aging and Center for Smell and Taste, University of Florida, Gainesville, Florida 32610, USA;
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- X.Z. Shawn Xu
- Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA;
説明
<jats:p> Temperature is a universal cue and regulates many essential processes ranging from enzymatic reactions to species migration. Due to the profound impact of temperature on physiology and behavior, animals and humans have evolved sophisticated mechanisms to detect temperature changes. Studies from animal models, such as mouse, Drosophila, and C. elegans, have revealed many exciting principles of thermosensation. For example, conserved molecular thermosensors, including thermosensitive channels and receptors, act as the initial detectors of temperature changes across taxa. Additionally, thermosensory neurons and circuits in different species appear to adopt similar logic to transduce and process temperature information. Here, we present the current understanding of thermosensation at the molecular and cellular levels. We also discuss the fundamental coding strategies of thermosensation at the circuit level. A thorough understanding of thermosensation not only provides key insights into sensory biology but also builds a foundation for developing better treatments for various sensory disorders. </jats:p>
収録刊行物
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- Annual Review of Physiology
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Annual Review of Physiology 83 (1), 205-230, 2021-02-10
Annual Reviews
