Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis
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- Shou‐Zen Fan
- Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan
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- Cheng‐Sheng Lin
- Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
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- Yu‐Wen Wei
- Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
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- Sheng‐Rong Yeh
- Department of Anesthesiology National Taiwan University Hospital National Taiwan University Taipei Taiwan
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- Yi‐Hsuan Tsai
- Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
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- Andrew Chengyu Lee
- Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
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- Wei‐Sheng Lin
- Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan
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- Pei‐Yu Wang
- Graduate Institute of Brain and Mind Sciences College of Medicine National Taiwan University Taipei Taiwan
抄録
<jats:title>Abstract</jats:title><jats:p>Citrate is an essential substrate for energy metabolism that plays critical roles in regulating cell growth and survival. However, the action of citrate in regulating metabolism, cognition, and aging at the organismal level remains poorly understood. Here, we report that dietary supplementation with citrate significantly reduces energy status and extends lifespan in <jats:italic>Drosophila melanogaster</jats:italic>. Our genetic studies in fruit flies implicate a molecular mechanism associated with AMP‐activated protein kinase (AMPK), target of rapamycin (TOR), and ketogenesis. Mice fed a high‐fat diet that supplemented with citrate or the ketone body β‐hydroxybutyrate (βOHB) also display improved metabolic health and memory. These results suggest that dietary citrate supplementation may prove to be a useful intervention in the future treatment of age‐related dysfunction.</jats:p>
収録刊行物
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- Aging Cell
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Aging Cell 20 (12), 2021-10-31
Wiley