説明
<jats:p>Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4<jats:sup>+</jats:sup> T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8<jats:sup>+</jats:sup> T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8<jats:sup>+</jats:sup> T lymphocytes, specifically describing the role of CD8<jats:sup>+</jats:sup> T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8<jats:sup>+</jats:sup> T cells to capitalize on the pathogenic and regulatory potential of CD8<jats:sup>+</jats:sup> T lymphocytes in SS to provide promising new strategies for this inflammatory disease.</jats:p>
収録刊行物
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- Frontiers in Immunology
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Frontiers in Immunology 11 602823-, 2021-01-28
Frontiers Media SA
