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- Junyue Cao
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
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- Diana R. O’Day
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
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- Hannah A. Pliner
- Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
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- Paul D. Kingsley
- Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
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- Mei Deng
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
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- Riza M. Daza
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
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- Michael A. Zager
- Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
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- Kimberly A. Aldinger
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
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- Ronnie Blecher-Gonen
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
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- Fan Zhang
- Illumina Inc., San Diego, CA, USA.
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- Malte Spielmann
- Human Molecular Genomics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany.
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- James Palis
- Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
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- Dan Doherty
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
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- Frank J. Steemers
- Illumina Inc., San Diego, CA, USA.
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- Ian A. Glass
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
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- Cole Trapnell
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
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- Jay Shendure
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
抄録
<jats:title>The genomics of human development</jats:title> <jats:p> Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples. Cao <jats:italic>et al.</jats:italic> focus on measurements of RNA in broadly distributed cell types and provide insights into organ specificity. Domcke <jats:italic>et al.</jats:italic> examined the chromatin accessibility of cells from these organs and identify the regulatory elements that regulate gene expression. Together, these analyses generate comprehensive atlases of early human development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7721">eaba7721</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7612">eaba7612</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 370 (6518), eaba7721-, 2020-11-13
American Association for the Advancement of Science (AAAS)
