Recent Advances in Catalytic Asymmetric Syntheses of Functionalized Heterocycles <i>via</i> Halogenation/Chalcogenation of Carbon‐Carbon Unsaturated Bonds

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  • Shengshu Liu
    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University 55 Daxuecheng South Road Shapingba Chongqing 401331 People's Republic of China
  • Bing‐Qian Zhang
    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University 55 Daxuecheng South Road Shapingba Chongqing 401331 People's Republic of China
  • Wen‐Ying Xiao
    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University 55 Daxuecheng South Road Shapingba Chongqing 401331 People's Republic of China
  • Yin‐Long Li
    Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston Massachusetts 02114 USA
  • Jun Deng
    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University 55 Daxuecheng South Road Shapingba Chongqing 401331 People's Republic of China

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<jats:title>Abstract</jats:title><jats:p>Halogen (fluorine, chlorine, bromine, iodine) or chalcogen (sulfur, selenium)‐containing heterocycles are widely recognized as key building blocks in many natural products and bioactive targets. Catalytic asymmetric halogenation/chalcogenation of carbon‐carbon unsaturated bonds <jats:italic>via</jats:italic> onium ion transformations are efficient methods to obtain diverse chiral heterocyclic backbones. In the past few years, catalytic enantioselective versions of halo/thio/seleno‐functionalizations with various halogen and chalcogen electrophiles have experienced constant development. This review highlights those advances in preparing functionalized heterocycles promoted by chiral organocatalysts or metal‐based catalysts.</jats:p><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/adsc202200611-toc-0001-m.png"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text> </jats:p>

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