InterPro in 2022

  • Typhaine Paysan-Lafosse
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Matthias Blum
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Sara Chuguransky
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Tiago Grego
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Beatriz Lázaro Pinto
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Gustavo A Salazar
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK
  • Maxwell L Bileschi
    Google Research, Brain team , Cambridge ,  MA ,  USA
  • Peer Bork
    European Molecular Biology Laboratory, Structural and Computational Biology Unit , Meyerhofstraße 1, 69117 Heidelberg , Germany
  • Alan Bridge
    Swiss-Prot Group, Swiss Institute of Bioinformatics , CMU, 1 rue Michel Servet, CH-1211, Geneva  4, Switzerland
  • Lucy Colwell
    Google Research, Brain team , Cambridge ,  MA ,  USA
  • Julian Gough
    Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus , Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK
  • Daniel H Haft
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , 8600 Rockville Pike, Bethesda , MD 20894 , USA
  • Ivica Letunić
    Biobyte Solutions GmbH , Bothestr 142, 69126 Heidelberg , Germany
  • Aron Marchler-Bauer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , 8600 Rockville Pike, Bethesda , MD 20894 , USA
  • Huaiyu Mi
    Division of Bioinformatics, Department of Preventive Medicine, University of Southern California , Los Angeles , CA 90033, USA
  • Darren A Natale
    Protein Information Resource, Georgetown University Medical Center , Washington , DC  20007 , USA
  • Christine A Orengo
    Department of Structural and Molecular Biology, University College London , Gower St, Bloomsbury, London WC1E 6BT, UK
  • Arun P Pandurangan
    Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus , Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK
  • Catherine Rivoire
    Swiss-Prot Group, Swiss Institute of Bioinformatics , CMU, 1 rue Michel Servet, CH-1211, Geneva  4, Switzerland
  • Christian J A Sigrist
    Swiss-Prot Group, Swiss Institute of Bioinformatics , CMU, 1 rue Michel Servet, CH-1211, Geneva  4, Switzerland
  • Ian Sillitoe
    Department of Structural and Molecular Biology, University College London , Gower St, Bloomsbury, London WC1E 6BT, UK
  • Narmada Thanki
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , 8600 Rockville Pike, Bethesda , MD 20894 , USA
  • Paul D Thomas
    Division of Bioinformatics, Department of Preventive Medicine, University of Southern California , Los Angeles , CA 90033, USA
  • Silvio C E Tosatto
    Department of Biomedical Sciences, University of Padua , via U. Bassi 58/b, 35131 Padua , Italy
  • Cathy H Wu
    Protein Information Resource, Georgetown University Medical Center , Washington , DC  20007 , USA
  • Alex Bateman
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK

抄録

<jats:title>Abstract</jats:title> <jats:p>The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (version 90.0) and its associated software, including updates to data content and to the website. These developments extend and enrich the information provided by InterPro, and provide a more user friendly access to the data. Additionally, we have worked on adding Pfam website features to the InterPro website, as the Pfam website will be retired in late 2022. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB. Moreover, we report the development of a card game as a method of engaging the non-scientific community. Finally, we discuss the benefits and challenges brought by the use of artificial intelligence for protein structure prediction.</jats:p>

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