GM-CSF in inflammation
-
- John A. Hamilton
- The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia 1
Description
<jats:p>Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions than its original in vitro identification as an inducer of granulocyte and macrophage development from progenitor cells. Key features of GM-CSF biology need to be defined better, such as the responding and producing cell types, its links with other mediators, its prosurvival versus activation/differentiation functions, and when it is relevant in pathology. Significant preclinical data have emerged from GM-CSF deletion/depletion approaches indicating that GM-CSF is a potential target in many inflammatory/autoimmune conditions. Clinical trials targeting GM-CSF or its receptor have shown encouraging efficacy and safety profiles, particularly in rheumatoid arthritis. This review provides an update on the above topics and current issues/questions surrounding GM-CSF biology.</jats:p>
Journal
-
- Journal of Experimental Medicine
-
Journal of Experimental Medicine 217 (1), 1-, 2019-10-14
Rockefeller University Press
- Tweet
Details 詳細情報について
-
- CRID
- 1360298762195287680
-
- ISSN
- 15409538
- 00221007
-
- Data Source
-
- Crossref