Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

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  • Liang Zhang
    The Institute For Advanced Studies Wuhan University Luojiashan Wuhan 430072 China
  • Shibo Wang
    The Institute For Advanced Studies Wuhan University Luojiashan Wuhan 430072 China
  • Yi Zhou
    Key Laboratory of Biomedical Polymers-Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Luojiashan Wuhan 430072 China
  • Chao Wang
    Key Laboratory of Biomedical Polymers-Ministry of Education College of Chemistry and Molecular Sciences Wuhan University Luojiashan Wuhan 430072 China
  • Xian‐Zheng Zhang
    The Institute For Advanced Studies Wuhan University Luojiashan Wuhan 430072 China
  • Hexiang Deng
    The Institute For Advanced Studies Wuhan University Luojiashan Wuhan 430072 China

説明

<jats:title>Abstract</jats:title><jats:p>Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5′,5′′′′‐(1,4‐phenylene)bis(([1,1′:3′,1′′‐terphenyl]‐4,4′′‐dicarbaldehyde)) (L‐3C) and 4,4′,4′′‐(1,4‐phenylene)bis(([2,2′:6′,2′′‐terpyridine]‐5,5′′‐dicarbaldehyde)) (L‐3N), inactive to generating reactive oxygen species (ROS), were linked to form two COFs, COF‐808 and COF‐909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 and 2610 m<jats:sup>2</jats:sup> g<jats:sup>−1</jats:sup>) promoted diffusion of both oxygen and release of ROS in cells. This, combined with the excellent photostability and biocompatibility, led to excellent PDT performance. In vitro, over 80 % of tumor cells were killed after PDT treatment using COF‐909 at the concentration of 50 μg mL<jats:sup>−1</jats:sup> for 150 s. In vivo, drastic reduction of tumor size was observed (from 9 mm to less than 1 mm) after 10 day treatment.</jats:p>

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