Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy
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- Hyunjoon Kim
- Department of Pharmaceutics
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- Drishti Sehgal
- Department of Pharmaceutics
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- Tamara A. Kucaba
- Department of Urology
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- David M. Ferguson
- Department of Medicinal Chemistry
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- Thomas S. Griffith
- Department of Urology
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- Jayanth Panyam
- Department of Pharmaceutics
説明
<p>Acidic-pH responsive PLGA NPs enhance endo/lysosomal delivery of the TLR7/8 agonist and elicit a stronger anti-tumor T cell response than conventional PLGA NPs.</p>
収録刊行物
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- Nanoscale
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Nanoscale 10 (44), 20851-20862, 2018
Royal Society of Chemistry (RSC)
