Lipid rafts in immune signalling: current progress and future perspective
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- Pallavi Varshney
- Functional Genomics Unit CSIR‐Institute of Genomics and Integrative Biology (CSIR‐IGIB) Delhi India
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- Vikas Yadav
- Functional Genomics Unit CSIR‐Institute of Genomics and Integrative Biology (CSIR‐IGIB) Delhi India
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- Neeru Saini
- Functional Genomics Unit CSIR‐Institute of Genomics and Integrative Biology (CSIR‐IGIB) Delhi India
説明
<jats:title>Summary</jats:title><jats:p>Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and regulatory molecules and so act as a platform for signal transduction. They float freely within the liquid‐disordered bilayer of cellular membranes and can cluster to form larger ordered domains. Alterations in lipid rafts are commonly found to be associated with the pathogenesis of several human diseases and recent reports have shown that the raft domains can also be perturbed by targeting raft proteins through micro<jats:styled-content style="fixed-case">RNA</jats:styled-content>s. Over the last few years, the importance of lipid rafts in modulating both innate and acquired immune responses has been elucidated. Various receptors present on immune cells like B cells, T cells, basophils and mast cells associate with lipid rafts on ligand binding and initiate signalling cascades leading to inflammation. Furthermore, disrupting lipid raft integrity alters lipopolysaccharide‐induced cytokine secretion, IgE signalling, and B‐cell and T‐cell activation. The objective of this review is to summarize the recent progress in understanding the role of lipid rafts in the modulation of immune signalling and its related therapeutic potential for autoimmune diseases and inflammatory disorders.</jats:p>
収録刊行物
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- Immunology
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Immunology 149 (1), 13-24, 2016-07-11
Wiley