Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors

  • Irene Lorenzo
    University Hospital of Guadalajara (SESCAM), Guadalajara
  • Nerea Fernández-de-Larrea
    Cancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III
  • Angelika Michel
    Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer (DKFZ), Research Center, Heidelberg, Germany
  • Beatriz Romero
    Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute
  • Virginia Lope
    Cancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III
  • Xavier Bessa
    Gastroenterology Department, Hospital del Mar
  • Victor Moreno
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Vicente Martín
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Pilar Amiano
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Jesús Castilla
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Adonina Tardón
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Trinidad Dierssen-Sotos
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Rosana Peiró
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Marian Díaz-Santos
    Natural Resources, Health and Environment Research Center, University of Huelva, Huelva (RENSMA)
  • Carmen Navarro
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • José J. Jiménez-Moleón
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Julia Butt
    Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute
  • Aurelio Barricarte
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Irune Ruiz
    Department of Pathology, Donostia University Hospital, Donostia
  • Antonio J. Molina-de-la-Torre
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Delphine Casabonne
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Beatriz Pérez-Gómez
    Cancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III
  • Manolis Kogevinas
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Rosa del Campo
    Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute
  • Silvia de Sanjosé
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)
  • Marina Pollán
    Cancer and Environmental Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III
  • Tim Waterboer
    Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer (DKFZ), Research Center, Heidelberg, Germany
  • Nuria Aragonés
    Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP)

抄録

<jats:p> <jats:italic toggle="yes">Helicobacter pylori</jats:italic> (<jats:italic toggle="yes">H. pylori</jats:italic>) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. The aim of this study was to describe the association of adult and childhood sociodemographic factors with the seroprevalence of <jats:italic toggle="yes">H. pylori</jats:italic>, and with CagA and VacA antigen-specific seropositivity among <jats:italic toggle="yes">H. pylori</jats:italic>-seropositive individuals in the Spanish adult population. Serum antibody reactivity to <jats:italic toggle="yes">H. pylori</jats:italic> proteins was evaluated using multiplex serology in 2555 population-based controls enrolled in the MCC-Spain study, a multicase–control study recruiting participants from 2008 to 2013 in different areas of Spain. <jats:italic toggle="yes">H. pylori</jats:italic> seroprevalence was defined as seropositivity against at least four bacterial proteins. Information on sociodemographics, lifestyles, and environmental exposures was collected through personal interviews. Prevalence ratios and 95% confidence intervals were estimated using Poisson regression models to assess the association of lifetime sociodemographic factors with <jats:italic toggle="yes">H. pylori</jats:italic> seroprevalence and with seropositivity for CagA and VacA. <jats:italic toggle="yes">H. pylori</jats:italic> seroprevalence was 87.2%. Seropositivity was statistically significantly higher in men, increased with age, BMI, and number of siblings, and decreased with education and socioeconomic family level at birth. Among <jats:italic toggle="yes">H. pylori</jats:italic>-seropositive individuals, seropositivity was 53.3% for CagA, 61.4% for VacA, and 38.8% for both CagA and VacA. Ever smokers had lower seroprevalence for CagA and VacA than never smokers. <jats:italic toggle="yes">H. pylori</jats:italic> seroprevalence among this Spanish adult population was high and one third of the population was seropositive for two well-known markers of gastric cancer risk: CagA and VacA. Sex, age, education, and BMI were associated with <jats:italic toggle="yes">H. pylori</jats:italic> seroprevalence.</jats:p>

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