A novel preoperative risk score to guide patient selection for resection of soft tissue sarcoma lung metastases: An analysis from the United States Sarcoma Collaborative
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- Rachel M. Lee
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Cecilia G. Ethun
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Adriana C. Gamboa
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Michael K. Turgeon
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Thuy Tran
- Department of Surgery Stanford University Medical Center Palo Alto California USA
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- George Poultsides
- Department of Surgery Stanford University Medical Center Palo Alto California USA
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- Valerie Grignol
- Department of Surgery, Division of Surgical Oncology The Ohio State University Columbus Ohio USA
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- Meena Bedi
- Department of Radiation Oncology Medical College of Wisconsin Milwaukee Wisconsin USA
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- Harveshp Mogal
- Department of Surgery Division of Surgical Oncology, Medical College of Wisconsin Milwaukee Wisconsin USA
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- Callisia N. Clarke
- Department of Surgery Division of Surgical Oncology, Medical College of Wisconsin Milwaukee Wisconsin USA
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- Jennifer Tseng
- Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA
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- Kevin K. Roggin
- Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA
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- Konstantinos Chouliaras
- Department of Surgery Wake Forest University Winston‐Salem North Carolina USA
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- Konstantinos Votanopoulos
- Department of Surgery Wake Forest University Winston‐Salem North Carolina USA
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- Bradley A. Krasnick
- Department of Surgery Washington University School of Medicine St Louis Missouri USA
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- Ryan C. Fields
- Department of Surgery Washington University School of Medicine St Louis Missouri USA
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- Shervin V. Oskouei
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- David K. Monson
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Nickolas B. Reimer
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Shishir K. Maithel
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
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- Allan Pickens
- Department of Surgery, Division of Cardiothoracic Surgery Emory University Atlanta Georgia USA
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- Kenneth Cardona
- Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute Emory University Atlanta Georgia USA
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Surgical resection for sarcoma lung metastases has been associated with improved overall survival (OS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients who underwent curative‐intent resection of sarcoma lung metastases (2000–2016) were identified from the US Sarcoma Collaborative. Patients with extrapulmonary metastatic disease or R2 resections of primary tumor or metastases were excluded. Primary endpoint was OS.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Three hundred and fifty‐two patients met inclusion criteria. Location of primary tumor was truncal/extremity in 85% (<jats:italic>n</jats:italic> = 270) and retroperitoneal in 15% (<jats:italic>n</jats:italic> = 49). Forty‐nine percent (<jats:italic>n</jats:italic> = 171) of patients had solitary and 51% (<jats:italic>n</jats:italic> = 180) had multiple lung metastasis. Median OS was 49 months; 5‐year OS 42%. Age ≥55 (HR 1.77), retroperitoneal primary (HR 1.67), R1 resection of primary (HR 1.72), and multiple (≥2) lung metastases (HR 1.77) were associated with decreased OS(all <jats:italic>p</jats:italic> < 0.05). Assigning one point for each factor, we developed a risk score from 0 to 4. Patients were then divided into two risk groups: low (0–1 factor) and high (2–4 factors). The low‐risk group (<jats:italic>n</jats:italic> = 159) had significantly better 5‐year OS compared to the high‐risk group (<jats:italic>n</jats:italic> = 108) (51% vs. 16%, <jats:italic>p</jats:italic> < 0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We identified four characteristics that in aggregate portend a worse OS and created a novel prognostic risk score for patients with sarcoma lung metastases. Given that patients in the high‐risk group have a projected OS of <20% at 5 years, this risk score, after external validation, will be an important tool to aid in preoperative counseling and consideration for multimodal therapy.</jats:p></jats:sec>
収録刊行物
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- Journal of Surgical Oncology
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Journal of Surgical Oncology 124 (8), 1477-1484, 2021-08-10
Wiley