Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist

DOI Web Site 被引用文献1件
  • Ling Liu
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Cristina Rodriguez-Mateo
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Polly Huang
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Albin Huang
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Alexander Lieu
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Michelle Mao
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Mingyu Chung
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Sharon Yang
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Kevin Yu
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Gregory W. Charville
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Qiang Gan
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  • Thomas A. Rando
    Paul F. Glenn Center for the Biology of Aging, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;

抄録

<jats:title>Significance</jats:title> <jats:p>Skeletal muscle stem cells (MuSCs) exhibit a high content of heterochromatin. However, little is known about the functional importance of heterochromatin maintenance in MuSC homeostasis. Our study uncovered the role of the Hairless (Hr) gene in protecting the integrity of heterochromatin in MuSCs. We characterized the molecular function of Hr and demonstrated its role as an antagonist to Histone 3 Lysine 9 demethylases. Our work has implications for the importance of heterochromatin maintenance in stem cell function during aging.</jats:p>

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