Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety

Yitao Li, Wenqiang Yao, Jian Lin, Falin Li, Yang Wu, Junxing Xu

doi:10.1002/jhet.3610

<jats:p>The triazole sulfonamide played a very important role in the field of research of new agrochemical compounds as a novel heterocyclic compound with lack of reported resistance. For the research on the innovative triazole sulfonamide fungicide effective against cucumber downy mildew (CDM), the present article designed an array of 1,2,4‐triazole‐1,3‐disulfonamide derivatives. The derivatives were synthesized <jats:italic>via</jats:italic> coupling multiple benzylamine with triazole sulfonamide groups. <jats:sup>1</jats:sup>H‐NMR, <jats:sup>13</jats:sup>C‐NMR, and LC–MS spectrometry were used to characterize these synthesized compounds. Most of these derivatives exhibited better fungicidal activities than that of the commercial cyanosole using bioassays. In particular, compounds <jats:bold>6g</jats:bold> and <jats:bold>6h</jats:bold> showed the best fungicidal activity against CDM (EC<jats:sub>50</jats:sub> = 6.91 and 10.62 mg/L). Comparative experiments demonstrated that the fungicidal activity of <jats:bold>6g</jats:bold> and <jats:bold>6h</jats:bold> was better than the commercial pesticides amisulbrom and cyanosole. According to the study, the compound <jats:bold>6g</jats:bold> had a giant application potential on fungicide against CDM.</jats:p>

Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety

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Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety

説明

収録刊行物

被引用文献 (3)*注記

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書き出し

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