Design, Synthesis, and Biological Activity of Novel Triazole Sulfonamide Derivatives Containing a Benzylamine Moiety
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- Yitao Li
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
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- Wenqiang Yao
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
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- Jian Lin
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
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- Falin Li
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
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- Yang Wu
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
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- Junxing Xu
- Dongguan HEC AgroSciences R&D Co., Ltd. Dongguan Guangdong 523867 People's Republic of China
説明
<jats:p>The triazole sulfonamide played a very important role in the field of research of new agrochemical compounds as a novel heterocyclic compound with lack of reported resistance. For the research on the innovative triazole sulfonamide fungicide effective against cucumber downy mildew (CDM), the present article designed an array of 1,2,4‐triazole‐1,3‐disulfonamide derivatives. The derivatives were synthesized <jats:italic>via</jats:italic> coupling multiple benzylamine with triazole sulfonamide groups. <jats:sup>1</jats:sup>H‐NMR, <jats:sup>13</jats:sup>C‐NMR, and LC–MS spectrometry were used to characterize these synthesized compounds. Most of these derivatives exhibited better fungicidal activities than that of the commercial cyanosole using bioassays. In particular, compounds <jats:bold>6g</jats:bold> and <jats:bold>6h</jats:bold> showed the best fungicidal activity against CDM (EC<jats:sub>50</jats:sub> = 6.91 and 10.62 mg/L). Comparative experiments demonstrated that the fungicidal activity of <jats:bold>6g</jats:bold> and <jats:bold>6h</jats:bold> was better than the commercial pesticides amisulbrom and cyanosole. According to the study, the compound <jats:bold>6g</jats:bold> had a giant application potential on fungicide against CDM.</jats:p>
収録刊行物
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- Journal of Heterocyclic Chemistry
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Journal of Heterocyclic Chemistry 56 (8), 2170-2178, 2019-07
Wiley
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360298764303658496
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- ISSN
- 19435193
- 0022152X
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- データソース種別
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- Crossref