Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial

  • Sonia Ruiz-Bustillo
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Consol Ivern
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Neus Badosa
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Nuria Farre
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Esther Marco
    Department of Physical Medicine and Rehabilitation, Hospital del Mar, Barcelona, Spain
  • Jordi Bruguera
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Mercè Cladellas
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Cristina Enjuanes
    Bellvitge University Hospital and Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
  • Miguel Cainzos-Achirica
    Bellvitge University Hospital and Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
  • Julio Marti-Almor
    Department of Cardiology, Hospital del Mar, Barcelona, Spain
  • Josep Comin-Colet
    Bellvitge University Hospital and Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

抄録

<jats:sec><jats:title>Background and aims:</jats:title><jats:p> Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an intensive lipid-lowering intervention, coordinated by nurses and implemented after hospital discharge, in patients hospitalized for an ischaemic heart disease event. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> Randomized controlled trial, in which a nurse-led intervention including periodic follow-up, serial lipid level controls, and subsequent optimization of lipid-lowering therapy, if appropriate, was compared with standard of care alone in terms of serum lipid-level control at six months after discharge. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> The nurse-led intervention was associated with an improved management of low-density lipoprotein (LDL) cholesterol levels compared with standard of care alone: LDL cholesterol levels ⩽100 mg/dL were achieved in 97% participants in the intervention arm as compared with 67% in the usual care arm ( p value <0.001), the LDL cholesterol ⩽70 mg/dL target recommended by the 2016 European Society of Cardiology guidelines was achieved in 62% vs. 37% participants ( p value 0.047) and the LDL cholesterol reduction of ⩾50% recommended by the American College of Cardiology/American Heart Association in 2013 was achieved in 25.6% of participants in the intervention arm as compared with 2.6% in the usual care arm ( p value 0.007). The intervention was also associated with improved blood pressure control among individuals with hypertension. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> Our findings highlight the opportunity that nurse-led, intensive, post-discharge follow-up plans may represent for achieving LDL cholesterol guideline-recommended management objectives in patients with ischaemic heart disease. These findings should be replicated in larger cohorts. </jats:p></jats:sec>

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