Organocatalyzed Kinetic Resolution of Racemic Carboxylic Acids

DOI 100 References
  • Ken Okuno
    Institute of Integrated Science and Technology Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan
  • Yasuaki Furuya
    Institute of Integrated Science and Technology Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan
  • Seiji Shirakawa
    Institute of Integrated Science and Technology Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan

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<jats:title>Abstract</jats:title><jats:p>The kinetic resolution of racemic compounds is a reliable method to prepare important chiral molecules in highly optically enriched forms. Although methods for the catalytic kinetic resolution of chiral alcohols, amines, and epoxides have been extensively investigated, the kinetic resolution of racemic carboxylic acids has remained under‐developed despite the importance of chiral carboxylic acids. Excellent catalytic approaches for the kinetic resolution of racemic carboxylic acids via esterification using chiral organocatalysts have been reported by several research groups. Furthermore, the organocatalyzed lactonization of alkenyl and alkynyl carboxylic acids has also been adapted to achieve kinetic resolution. Herein, the methods typically used to produce the organocatalyzed kinetic resolution of racemic carboxylic acids are reviewed to elucidate the current status of this research.</jats:p>

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Details 詳細情報について

  • CRID
    1360302865552199680
  • DOI
    10.1002/ejoc.202300985
  • ISSN
    10990690
    1434193X
  • Article Type
    journal article
  • Data Source
    • Crossref
    • KAKEN
    • OpenAIRE

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