Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms
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- Maurício S. Baptista
- Instituto de Química Universidade de São Paulo São Paulo Brazil
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- Jean Cadet
- Département de Médecine Nucléaire et de Radiobiologie Université de Sherbrooke Sherbrooke QC Canada
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- Alexander Greer
- Department of Chemistry Brooklyn College Brooklyn NY USA
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- Andrés H. Thomas
- Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA) Departamento de Química Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP) CCT La Plata‐CONICET La Plata Argentina
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説明
<jats:title>Abstract</jats:title><jats:p>Photosensitization reactions have been demonstrated to be largely responsible for the deleterious biological effects of UV and visible radiation, as well as for the curative actions of photomedicine. A large number of endogenous and exogenous photosensitizers, biological targets and mechanisms have been reported in the past few decades. Evolving from the original definitions of the type I and type II photosensitized oxidations, we now provide physicochemical frameworks, classifications and key examples of these mechanisms in order to organize, interpret and understand the vast information available in the literature and the new reports, which are in vigorous growth. This review surveys in an extended manner all identified photosensitization mechanisms of the major biomolecule groups such as nucleic acids, proteins, lipids bridging the gap with the subsequent biological processes. Also described are the effects of photosensitization in cells in which UVA and UVB irradiation triggers enzyme activation with the subsequent delayed generation of superoxide anion radical and nitric oxide. Definitions of photosensitized reactions are identified in biomolecules with key insights into cells and tissues.</jats:p>
収録刊行物
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- Photochemistry and Photobiology
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Photochemistry and Photobiology 97 (6), 1456-1483, 2021-07-08
Wiley
