Elevated Risk of Dementia Diagnosis in Older Adults with Low Frequencies and Durations of Social Conversation
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- Hiroyuki Shimada
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Takehiko Doi
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Kota Tsutsumimoto
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Keitaro Makino
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Kenji Harada
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Kouki Tomida
- Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan
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- Hidenori Arai
- National Center for Geriatrics and Gerontology, Obu, Japan
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<jats:sec specific-use="heading-level-1"> <jats:title>Background:</jats:title> <jats:p>Social networks and social participation have protective effects on cognitive function maintenance and Alzheimer’s disease and general dementia development.</jats:p> </jats:sec> <jats:sec specific-use="heading-level-1"> <jats:title>Objective:</jats:title> <jats:p>We aimed to investigate the association between conversations and dementia incidence in older adults.</jats:p> </jats:sec> <jats:sec specific-use="heading-level-1"> <jats:title>Methods:</jats:title> <jats:p>This longitudinal prospective cohort study used population data from the National Center for Geriatric and Gerontology–Study of Geriatric Syndromes (NCGG–SGS) from September 2015 to February 2017. The database included 4,167 individuals in Japan aged ≥60 years who were generally healthy and without major cognitive impairment. Participants were classified into two groups according to six daily conversation measures at baseline. The conversation index was calculated as a composite score for these measures. Participants were tracked monthly over 60 months for new-onset dementia.</jats:p> </jats:sec> <jats:sec specific-use="heading-level-1"> <jats:title>Results:</jats:title> <jats:p>Data from 2,531 participants were analyzed (72.7±6.7 years; range: 60–96 years). Dementia incidence per 1,000 person-years was 15.7 (95% confidence interval, 13.6–18.1). The Youden index determined the cut-off point for dementia incidence, with a conversation index of 16/17 points. The low conversation group included more participants with new-onset dementia. Cox proportional hazards regression crude models showed remarkable relationships between dementia onset and specific conversation measurements, including conversation index. According to the Cox regression adjusted model, the cut-off point of the conversation index showed only a remarkable relationship with dementia onset.</jats:p> </jats:sec> <jats:sec specific-use="heading-level-1"> <jats:title>Conclusions:</jats:title> <jats:p>Dementia risk was extensively associated with low daily conversation statuses. The assessment of conversational factors may be useful as a risk indicator for the development of Alzheimer’s disease and general dementia.</jats:p> </jats:sec>
収録刊行物
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- Journal of Alzheimer’s Disease
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Journal of Alzheimer’s Disease 98 (2), 659-669, 2024-03-08
SAGE Publications
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詳細情報 詳細情報について
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- CRID
- 1360302870464498304
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- ISSN
- 18758908
- 13872877
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- データソース種別
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- Crossref
- OpenAIRE