Understanding the Impact of the P-loop Conformation on Kinase Selectivity

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  • Cristiano R. W. Guimarães
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Brajesh K. Rai
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Michael J. Munchhof
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Shenping Liu
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Jian Wang
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Samit K. Bhattacharya
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
  • Leonard Buckbinder
    Worldwide Medicinal Chemistry Department, ‡Computational Sciences Center of Emphasis, §Department of Structural Biology and Biophysics, and ∥CVMED - Target Exploration, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

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