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- Robby Divine
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Ha V. Dang
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- George Ueda
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Jorge A. Fallas
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Ivan Vulovic
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- William Sheffler
- Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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- Shally Saini
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Yan Ting Zhao
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Infencia Xavier Raj
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Peter A. Morawski
- Benaroya Research Institute, Seattle, WA 98101, USA.
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- Madeleine F. Jennewein
- Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Leah J. Homad
- Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Yu-Hsin Wan
- Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Marti R. Tooley
- Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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- Franziska Seeger
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Ali Etemadi
- Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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- Mitchell L. Fahning
- Benaroya Research Institute, Seattle, WA 98101, USA.
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- James Lazarovits
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Alex Roederer
- Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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- Alexandra C. Walls
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Lance Stewart
- Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
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- Mohammadali Mazloomi
- Medical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
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- Neil P. King
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Daniel J. Campbell
- Benaroya Research Institute, Seattle, WA 98101, USA.
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- Andrew T. McGuire
- Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Leonidas Stamatatos
- Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98019, USA.
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- Hannele Ruohola-Baker
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- Julie Mathieu
- Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
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- David Veesler
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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- David Baker
- Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
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説明
<jats:title>Integrating form and function for design</jats:title> <jats:p> Antibodies are broadly used in therapies and as research tools because they can be generated against a wide range of targets. Efficacy can often be increased by clustering antibodies in multivalent assemblies. Divine <jats:italic>et al.</jats:italic> designed antibody nanocages from two components: One is an antibody-binding homo-oligomic protein and the other is the antibody itself. Computationally designed proteins drive the assembly of antibody nanocages in a range of architectures, allowing control of the symmetry and the antibody valency. The multivalent display enhances antibody-dependent signaling, and nanocages displaying antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein effectively neutralize pseudovirus. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd9994">eabd9994</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 372 (6537), eabd9994-, 2021-04-02
American Association for the Advancement of Science (AAAS)
