Chemically Stable, Strongly Adhesive Sealant Patch for Intestinal Anastomotic Leakage Prevention

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  • Alexandre H. C. Anthis
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Xueqian Hu
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Martin T. Matter
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Anna L. Neuer
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Kongchang Wei
    Laboratory for Biomimetic Membranes and Textiles Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Andrea A. Schlegel
    Liver Unit Queen Elizabeth University Hospital Birmingham Mindelsohn Way Birmingham B15 2WB UK
  • Fabian H.L. Starsich
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland
  • Inge K. Herrmann
    Laboratory for Particles Biology Interactions Department Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen CH‐9014 Switzerland

書誌事項

公開日
2021-02
権利情報
  • http://creativecommons.org/licenses/by-nc/4.0/
DOI
  • 10.1002/adfm.202007099
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Intestinal anastomotic leaking, which involves the discharge of chemically aggressive, non‐sterile fluids into the abdomen, remains one of the most dreaded postoperative complications of abdominal surgery. Depending on the site and the patient condition, incidence ranging between 4% and 21% and mortality rates up to 27% are reported. Currently available surgical sealants only poorly address the issue, especially since most commonly used fibrin glues fail due to insufficient adhesion and chemical instability. Here, a chemically highly resistive, leak‐tight, and mucoadhesive hydrogel sealant, which is grafted on the surface of the intestinal wall using a mutually interpenetrating network that traverses hydrogel and tissue is presented. In contrast to clinically used fibrin‐based sealants (including Tachosil), the developed adhesive poly(acrylamide‐methyl acrylate‐acrylic acid) patch does not degrade and exhibits strong tissue adhesion even when exposed to intestinal fluid. The biocompatible hydrogel patch effectively seals anastomotic leaks in ex vivo intestinal models, greatly surpassing commercial sealants (time to patch‐failure >24 h compared to 5 min for commonly used Tachosil). Importantly, the developed adhesive patch paves the way for the application of both mechanically and chemically robust sealants suitable for the treatment and prevention of intestinal leaks.</jats:p>

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