Exosomal miR‐6803‐5p as potential diagnostic and prognostic marker in colorectal cancer

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  • Shushan Yan
    Department of Gastrointestinal and Anal Diseases Surgery The Affiliated Hospital of Weifang Medical University Weifang China
  • Ye Jiang
    Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing China
  • Caihong Liang
    Department of Cardiovascular The Affiliated Jiangning Hospital of Nanjing Medical University Nanjing China
  • Min Cheng
    Department of Physiology Weifang Medical University Weifang China
  • Chengwen Jin
    Functional Laboratory Clinical Medicine College of Weifang Medical University Weifang China
  • Quanhong Duan
    Department of Gastrointestinal and Anal Diseases Surgery The Affiliated Hospital of Weifang Medical University Weifang China
  • Donghua Xu
    Department of Rheumatology and Immunology The Affiliated Hospital of Weifang Medical University Weifang China
  • Lu Yang
    Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing China
  • Xiaoyu Zhang
    Division of Gastrointestinal Surgery Department of General Surgery Huai'an Second People's Hospital The Affiliated Huai'an Hospital of Xuzhou Medical University Huai'an China
  • Bin Ren
    Department of Gastrointestinal and Anal Diseases Surgery The Affiliated Hospital of Weifang Medical University Weifang China
  • Peng Jin
    Department of Gastrointestinal and Anal Diseases Surgery The Affiliated Hospital of Weifang Medical University Weifang China

書誌事項

公開日
2018-01-25
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/jcb.26609
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:sec><jats:label/><jats:p>Accumulating data have suggested exosome‐delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR‐6803‐5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR‐6803‐5p were determined by microarray analysis and verified by quantitative real‐time PCR (qRT‐PCR). Outcomes of overall survival (OS) and disease‐free survival (DFS) of CRC patients were estimated by Kaplan‐Meier analysis. We used cox regression analysis to investigate the association between exosomes‐encapsulated miR‐6803‐5p and the clinicopathological factors of CRC patients. The exosomal miR‐6803‐5p was significantly increased in serum samples from patients with CRC in contrast to healthy controls. Significantly higher levels of serum exosomal miR‐6803‐5p were observed in CRC patients at later TNM stage or with lymph node metastasis as well as liver metastasis. Patients with elevated levels of serum exosomal miR‐6803‐5p had much poorer OS and DFS. Cox regression analysis revealed high levels of exosomal miR‐6803‐5p was associated with poor prognosis in CRC independent of other confounding factors. Thus, exosomal miR‐6803‐5p is a potential diagnostic and prognostic biomarker for patients with CRC.</jats:p></jats:sec>

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