An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma

  • Elshad Hasanov
    Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas
  • Debra Nana Yeboa
    Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas
  • Mathew D. Tucker
    Department of Medicine, Division of Hematology and Oncology Vanderbilt University Medical Center Nashville Tennessee
  • Todd A. Swanson
    Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas
  • Thomas Hendrix Beckham
    Department of Radiation Oncology, Division of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas
  • Brian Rini
    Department of Medicine, Division of Hematology and Oncology Vanderbilt University Medical Center Nashville Tennessee
  • Chibawanye I. Ene
    Department of Neurosurgery, Division of Surgery The University of Texas MD Anderson Cancer Center Houston Texas
  • Merve Hasanov
    Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas
  • Sophie Derks
    Department of Radiology and Nuclear Medicine, Erasmus Medical Center University Medical Center Rotterdam Rotterdam the Netherlands
  • Marion Smits
    Department of Radiology and Nuclear Medicine, Erasmus Medical Center University Medical Center Rotterdam Rotterdam the Netherlands
  • Shaan Dudani
    Division of Oncology/Hematology William Osler Health System Brampton Ontario Canada
  • Daniel Y. C. Heng
    Tom Baker Cancer Center University of Calgary Calgary Alberta Canada
  • Priscilla K. Brastianos
    Division of Neuro‐Oncology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts
  • Axel Bex
    The Royal Free London National Health Service Foundation Trust London United Kingdom
  • Sahin Hanalioglu
    Department of Neurosurgery Hacettepe University Faculty of Medicine Ankara Turkey
  • Jeffrey S. Weinberg
    Department of Neurosurgery, Division of Surgery The University of Texas MD Anderson Cancer Center Houston Texas
  • Laure Hirsch
    Department of Medical Oncology Cochin University Hospital, Public Assistance Hospital of Paris Paris France
  • Maria I. Carlo
    Genitourinary Oncology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York New York
  • Ayal Aizer
    Department of Radiation Oncology Brigham and Women's Hospital, Dana‐Farber Cancer Institute, Harvard Medical School Boston Massachusetts
  • Paul David Brown
    Department of Radiation Oncology Mayo Clinic Rochester Minnesota
  • Mehmet Asim Bilen
    Department of Hematology and Medical Oncology Emory University School of Medicine Atlanta Georgia
  • Eric Lin Chang
    Department of Radiation Oncology University of Southern California, Keck School of Medicine California Los Angeles
  • Jerry Jaboin
    Department of Radiation Medicine Oregon Health & Science University Portland Oregon
  • James Brugarolas
    Kidney Cancer Program, Simmons Comprehensive Cancer Center The University of Texas Southwestern Medical Center Dallas Texas
  • Toni K. Choueiri
    Lank Center for Genitourinary Oncology Dana‐Farber Cancer Institute Boston Massachusetts
  • Michael B. Atkins
    Lombardi Comprehensive Cancer Center MedStar Georgetown University Hospital Washington DC
  • Bradley A. McGregor
    Lank Center for Genitourinary Oncology Dana‐Farber Cancer Institute Boston Massachusetts
  • Lia M. Halasz
    Department of Radiation Oncology University of Washington Seattle Washington
  • Toral R. Patel
    Kidney Cancer Program, Simmons Comprehensive Cancer Center The University of Texas Southwestern Medical Center Dallas Texas
  • Scott G. Soltys
    Department of Radiation Oncology Stanford Cancer Institute Stanford California
  • David F. McDermott
    Division of Medical Oncology Beth Israel Deaconess Medical Center Boston Massachusetts
  • James Bradley Elder
    Department of Neurological Surgery Ohio State University Wexner Medical Center Columbus Ohio
  • Mustafa K. Baskaya
    Department of Neurological Surgery University of Wisconsin‐Madison, School of Medicine and Public Health Madison Wisconsin
  • James B. Yu
    Department of Therapeutic Radiology Yale University School of Medicine New Haven Connecticut
  • Robert Timmerman
    Kidney Cancer Program, Simmons Comprehensive Cancer Center The University of Texas Southwestern Medical Center Dallas Texas
  • Michelle Miran Kim
    Department of Radiation Oncology University of Michigan Ann Arbor Michigan
  • Melike Mut
    Department of Neurosurgery Hacettepe University Faculty of Medicine Ankara Turkey
  • James Markert
    Department of Neurosurgery The University of Alabama at Birmingham Birmingham Alabama
  • Kathryn Beal
    Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York
  • Nizar M. Tannir
    Department of Genitourinary Medical Oncology, Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas
  • George Samandouras
    Victor Horsley Department of Neurosurgery The National Hospital for Neurology and Neurosurgery, Queen Square London United Kingdom
  • Frederick F. Lang
    Department of Neurosurgery, Division of Surgery The University of Texas MD Anderson Cancer Center Houston Texas
  • Rachel Giles
    International Kidney Cancer Coalition Duivendrecht the Netherlands
  • Eric Jonasch
    Department of Genitourinary Medical Oncology, Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas

書誌事項

公開日
2022-06-16
権利情報
  • http://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
  • 10.3322/caac.21729
公開者
Wiley

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説明

<jats:title>Abstract</jats:title> <jats:p> Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. <jats:bold>CA Cancer J Clin. 2022;72:454‐489.</jats:bold> </jats:p>

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