Ir(III)‐Catalyzed C7‐Position‐Selective Oxidative CH Alkenylation of Indolines with Alkenes in Air

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Abstract

<jats:title>Abstract</jats:title><jats:p>An efficient method for C7‐position‐selective alkenylation of <jats:italic>N</jats:italic>‐substituted indolines with alkenes is reported. Various 7‐alkenylindolines were obtained in moderate to excellent yields in air in the presence of catalytic amounts of [Cp*IrCl<jats:sub>2</jats:sub>]<jats:sub>2</jats:sub>, AgOTf, and Cu(OAc)<jats:sub>2</jats:sub>. The protocol relies on the use of a carbonyl or carbamoyl group on the nitrogen atom of indoline as a directing group and is potentially applicable to the synthesis of 7‐alkenylindoles and 7‐alkylindoles.</jats:p>

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