Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

DOI Web Site Web Site PubMed 被引用文献38件 参考文献52件

書誌事項

公開日
2015-08
資源種別
journal article
権利情報
  • https://www.elsevier.com/tdm/userlicense/1.0/
  • https://www.elsevier.com/open-access/userlicense/1.0/
DOI
  • 10.1016/j.cell.2015.07.026
公開者
Elsevier BV

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説明

Compensatory proliferation triggered by hepatocyte loss is required for liver regeneration and maintenance but also promotes development of hepatocellular carcinoma (HCC). Despite extensive investigation, the cells responsible for hepatocyte restoration or HCC development remain poorly characterized. We used genetic lineage tracing to identify cells responsible for hepatocyte replenishment following chronic liver injury and queried their roles in three distinct HCC models. We found that a pre-existing population of periportal hepatocytes, located in the portal triads of healthy livers and expressing low amounts of Sox9 and other bile-duct-enriched genes, undergo extensive proliferation and replenish liver mass after chronic hepatocyte-depleting injuries. Despite their high regenerative potential, these so-called hybrid hepatocytes do not give rise to HCC in chronically injured livers and thus represent a unique way to restore tissue function and avoid tumorigenesis. This specialized set of pre-existing differentiated cells may be highly suitable for cell-based therapy of chronic hepatocyte-depleting disorders.

収録刊行物

  • Cell

    Cell 162 (4), 766-779, 2015-08

    Elsevier BV

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