Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

DOI HANDLE PDF Web Site PubMed 研究データあり 被引用文献1件 参考文献49件 オープンアクセス

書誌事項

公開日
2016-08-31
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0
  • https://creativecommons.org/licenses/by/4.0
DOI
  • 10.1038/ncomms12597
公開者
Springer Science and Business Media LLC

説明

<jats:title>Abstract</jats:title><jats:p>A population of monocytes, known as Ly6C<jats:sup>lo</jats:sup> monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6C<jats:sup>hi</jats:sup> monocytes into Ly6C<jats:sup>lo</jats:sup> monocytes <jats:italic>in vivo</jats:italic> and <jats:italic>in vitro,</jats:italic> thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen <jats:italic>in vivo</jats:italic>, while culture on recombinant DLL1 induces monocyte conversion <jats:italic>in vitro</jats:italic>. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.</jats:p>

収録刊行物

  • Nature Communications

    Nature Communications 7 (1), 12597-, 2016-08-31

    Springer Science and Business Media LLC

被引用文献 (1)*注記

もっと見る

参考文献 (49)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ