Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DOI HANDLE HANDLE HANDLE HANDLE ほか5件をすべて表示 一部だけ表示 被引用文献26件 参考文献51件 オープンアクセス

書誌事項

公開日
2014-02-09
資源種別
journal article
権利情報
  • http://www.springer.com/tdm
DOI
  • 10.1038/ng.2897
公開者
Springer Science and Business Media LLC

この論文をさがす

説明

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

収録刊行物

  • Nature Genetics

    Nature Genetics 46 (3), 234-244, 2014-02-09

    Springer Science and Business Media LLC

被引用文献 (26)*注記

もっと見る

参考文献 (51)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ