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説明
We describe Rosetta-based computational protocols for predicting the 3D structure of an antibody from sequence (RosettaAntibody) and then docking the antibody to protein antigens (SnugDock). Antibody modeling leverages canonical loop conformations to graft large segments from experimentally determined structures, as well as offering (i) energetic calculations to minimize loops, (ii) docking methodology to refine the V
収録刊行物
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- Nature Protocols
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Nature Protocols 12 (2), 401-416, 2017-01-26
Springer Science and Business Media LLC
