Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells
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説明
We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4-10) and ionic strength (0-500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as "walking nanothermometers".
収録刊行物
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- Lab on a Chip
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Lab on a Chip 12 (9), 1591-, 2012
Royal Society of Chemistry (RSC)