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Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment
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- Kazuhiro Kawamura
- Department of Obstetrics and Gynecology and
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- Yuan Cheng
- Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
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- Nao Suzuki
- Department of Obstetrics and Gynecology and
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- Masashi Deguchi
- Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
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- Yorino Sato
- Department of Obstetrics and Gynecology and
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- Seido Takae
- Department of Obstetrics and Gynecology and
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- Chi-hong Ho
- Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
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- Nanami Kawamura
- Department of Advanced Reproductive Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan;
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- Midori Tamura
- Department of Obstetrics and Gynecology and
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- Shu Hashimoto
- IVF Namba Clinic, Osaka, Osaka 550-0015, Japan; and
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- Yodo Sugishita
- Department of Obstetrics and Gynecology and
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- Yoshiharu Morimoto
- IVF Namba Clinic, Osaka, Osaka 550-0015, Japan; and
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- Yoshihiko Hosoi
- Graduate School of Biology-Oriented Science and Technology, Kinki University, Wakayama, Wakayama 649-6493, Japan
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- Nobuhito Yoshioka
- Department of Obstetrics and Gynecology and
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- Bunpei Ishizuka
- Department of Advanced Reproductive Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan;
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- Aaron J. Hsueh
- Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
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Description
<jats:title>Significance</jats:title> <jats:p>Human ovaries hold follicles containing oocytes. When follicles mature, they release eggs for fertilization. Patients with primary ovarian insufficiency develop menopausal symptoms at less than 40 y of age. They have few remaining follicles and their only chance for bearing a baby is through egg donation. Kawamura et al. demonstrated that Hippo and Akt signaling pathways regulate follicle growth. Using an in vitro activation approach, they first removed ovaries from infertile patients, followed by fragmentation to disrupt Hippo signaling and drug treatment to stimulate Akt signaling. After grafting ovarian tissues back to patients, they found rapid follicle growth in some patients and successfully retrieved mature eggs. After in vitro fertilization and embryo transfer, a live birth is now reported.</jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (43), 17474-17479, 2013-09-30
Proceedings of the National Academy of Sciences
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Keywords
- Adult
- Male
- Immunoblotting
- Oocyte Retrieval
- Fertilization in Vitro
- Mice, SCID
- Primary Ovarian Insufficiency
- Protein Serine-Threonine Kinases
- Mice
- Ovarian Follicle
- Pregnancy
- Animals
- Humans
- Hippo Signaling Pathway
- Reverse Transcriptase Polymerase Chain Reaction
- Infant, Newborn
- Pregnancy Outcome
- Embryo Transfer
- Treatment Outcome
- Female
- Infertility, Female
- Proto-Oncogene Proteins c-akt
- Signal Transduction
Details 詳細情報について
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- CRID
- 1360565167086207232
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- ISSN
- 10916490
- 00278424
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- PubMed
- 24082083
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- Article Type
- journal article
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE
