Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy
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- Masako Nagashima
- Jichi Medical University, Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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- Yukifumi Monden
- Jichi Medical University, Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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- Ippeita Dan
- Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapandChuo University, Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan
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- Haruka Dan
- Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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- Tsutomu Mizutani
- Jichi Medical University, Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapancJichi Medical University, Functional Brain Science Laboratory, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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- Daisuke Tsuzuki
- Chuo University, Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan
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- Yasushi Kyutoku
- Chuo University, Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan
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- Yuji Gunji
- Jichi Medical University, Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapaneInternational University of Health and Welfare, Department of Pediatrics, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan
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- Daisuke Hirano
- International University of Health and Welfare, 2600-1, Kitakanemaru, Otawara, Tochigi 324-8501, Japan
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- Takamichi Taniguchi
- International University of Health and Welfare, 2600-1, Kitakanemaru, Otawara, Tochigi 324-8501, Japan
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- Hideo Shimoizumi
- International University of Health and Welfare, Rehabilitation Center, 2600-1, Kitakanemaru, Otawara, Tochigi 324-8501, Japan
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- Mariko Y. Momoi
- International University of Health and Welfare, Department of Pediatrics, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, JapanfInternational University of Health and Welfare, 2600-1, Kitakanemaru, Otawara, Tochigi 324-8501, Japan
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- Takanori Yamagata
- Jichi Medical University, Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
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- Eiju Watanabe
- Jichi Medical University, Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
Description
The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.
Journal
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- Neurophotonics
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Neurophotonics 1 (2), 025007-, 2014-10-01
SPIE-Intl Soc Optical Eng