CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage
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- Hiroki Abe
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Susumu Jitsuki
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Waki Nakajima
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Yumi Murata
- Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, 305-8568, Japan.
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- Aoi Jitsuki-Takahashi
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Yuki Katsuno
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Hirobumi Tada
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Akane Sano
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Kumiko Suyama
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Nobuyuki Mochizuki
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Takashi Komori
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Hitoshi Masuyama
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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- Tomohiro Okuda
- Toyama Chemical Co., Tokyo, 160-0023, Japan.
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- Yoshio Goshima
- Yokohama City University Graduate School of Medicine, Department of Molecular Pharmacology and Neurobiology, Yokohama, 236-0004, Japan.
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- Noriyuki Higo
- Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, 305-8568, Japan.
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- Takuya Takahashi
- Yokohama City University Graduate School of Medicine, Department of Physiology, Yokohama, 236-0004, Japan.
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<jats:title>A small molecule for stroke therapy</jats:title> <jats:p> Better therapies for motor impairments after stroke are greatly needed. In mice and nonhuman primates, Abe <jats:italic>et al.</jats:italic> found that edonerpic maleate enhanced synaptic plasticity and functional recovery after a traumatic insult to the brain (see the Perspective by Rumpel). This recovery of motor function was accompanied by functional reorganization of the cortex. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="50" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao2300">50</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="30" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat2450">30</jats:related-article> </jats:p>
Journal
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- Science
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Science 360 (6384), 50-57, 2018-04-06
American Association for the Advancement of Science (AAAS)