Regulation of Epithelial Sodium Transport via Epithelial Na<sup>+</sup>Channel
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- Yoshinori Marunaka
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Naomi Niisato
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Akiyuki Taruno
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Mariko Ohta
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Hiroaki Miyazaki
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Shigekuni Hosogi
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Ken-ichi Nakajima
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Katsuyuki Kusuzaki
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Eishi Ashihara
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Kyosuke Nishio
- Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Yoshinobu Iwasaki
- Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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- Takashi Nakahari
- Department of Physiology, Osaka Medical College, Takatsuki 569-8686, Japan
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- Takahiro Kubota
- Department of Physiology, Osaka Medical College, Takatsuki 569-8686, Japan
抄録
<jats:p>Renal epithelial Na<jats:sup>+</jats:sup>transport plays an important role in homeostasis of our body fluid content and blood pressure. Further, the Na<jats:sup>+</jats:sup>transport in alveolar epithelial cells essentially controls the amount of alveolar fluid that should be kept at an appropriate level for normal gas exchange. The epithelial Na<jats:sup>+</jats:sup>transport is generally mediated through two steps: (1) the entry step of Na<jats:sup>+</jats:sup>via epithelial Na<jats:sup>+</jats:sup>channel (ENaC) at the apical membrane and (2) the extrusion step of Na<jats:sup>+</jats:sup>via the Na<jats:sup>+</jats:sup>, K<jats:sup>+</jats:sup>-ATPase at the basolateral membrane. In general, the Na<jats:sup>+</jats:sup>entry via ENaC is the rate-limiting step. Therefore, the regulation of ENaC plays an essential role in control of blood pressure and normal gas exchange. In this paper, we discuss two major factors in ENaC regulation: (1) activity of individual ENaC and (2) number of ENaC located at the apical membrane.</jats:p>
収録刊行物
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- Journal of Biomedicine and Biotechnology
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Journal of Biomedicine and Biotechnology 2011 1-8, 2011
Hindawi Limited
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詳細情報 詳細情報について
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- CRID
- 1360565168619521024
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- ISSN
- 11107251
- 11107243
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- データソース種別
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