SYNTHESIS OF NEOBAVAISOFLAVONE

Mitsuru Nakayama, Shûichi Hayashi, Mitsuo Masumura, Tokunaru Horie, Masao Tsukayama, Toshihide Yamada

doi:10.1002/chin.197545280

SYNTHESIS OF NEOBAVAISOFLAVONE

Mitsuru Nakayama

Department of Chemistry, Faculty of Science, Hiroshima University
Shûichi Hayashi

Department of Chemistry, Faculty of Science, Hiroshima University
Mitsuo Masumura

Department of Applied Chemistry, Faculty of Engineering, Tokushima University
Tokunaru Horie

Department of Applied Chemistry, Faculty of Engineering, Tokushima University
Masao Tsukayama

Department of Applied Chemistry, Faculty of Engineering, Tokushima University
Toshihide Yamada

Department of Applied Chemistry, Faculty of Engineering, Tokushima University

説明

<jats:title>Abstract</jats:title> <jats:p>Condensation of 7-benzoyldaidzein (III) with 2-methyl-3-buten-2-ol gave 7-benzoyl-3′-(3-methyl-2-butenyl)daidzein (IV). Hydrolysis of IV with dilute alkali gave 3′-(3-methyl-2-butenyl)daidzein (neobavaisoflavone) (I), which was converted into isoneobavaisoflavone (VI) when heated with formic acid. 7-Benzyldaidzein (VII) was condensed with 2-methyl-3-buten-2-ol to give a chroman derivative (VIII), which was converted into VI by hydrogenolysis.</jats:p>