Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle
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- Hiroaki Eshima
- Department of Metabolism & Endocrinology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Yoshifumi Tamura
- Department of Metabolism & Endocrinology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Saori Kakehi
- Department of Metabolism & Endocrinology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Nagomi Kurebayashi
- Department of Cellular and Molecular Pharmacology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Takashi Murayama
- Department of Cellular and Molecular Pharmacology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Kyoko Nakamura
- Department of Physiology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Ryo Kakigi
- Department of Physiology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Takao Okada
- Department of Physiology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Takashi Sakurai
- Department of Cellular and Molecular Pharmacology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Ryuzo Kawamori
- Department of Metabolism & Endocrinology; Juntendo University Graduate School of Medicine; Tokyo Japan
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- Hirotaka Watada
- Department of Metabolism & Endocrinology; Juntendo University Graduate School of Medicine; Tokyo Japan
Description
In this study, we investigated the effects of a short-term and long-term high-fat diet (HFD) on morphological and functional features of fast-twitch skeletal muscle. Male C57BL/6J mice were fed a HFD (60% fat) for 4 weeks (4-week HFD) or 12 weeks (12-week HFD). Subsequently, the fast-twitch extensor digitorum longus muscle was isolated, and the composition of muscle fiber type, expression levels of proteins involved in muscle contraction, and force production on electrical stimulation were analyzed. The 12-week HFD, but not the 4-week HFD, resulted in a decreased muscle tetanic force on 100 Hz stimulation compared with control (5.1 ± 1.4 N/g in the 12-week HFD vs. 7.5 ± 1.7 N/g in the control group;
Journal
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- Physiological Reports
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Physiological Reports 5 (7), e13250-, 2017-04
Wiley
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Keywords
- Male
- Myosin Heavy Chains
- Skeletal Muscle
- Diet, High-Fat
- Lipid Metabolism
- muscle fiber composition
- muscle contractile force
- High‐fat diet
- Mitochondria
- Mice, Inbred C57BL
- Mice
- insulin resistance
- Muscle Fibers, Fast-Twitch
- Animals
- Muscle Contraction and Relaxation
- Adipose Tissue and Obesity
- Muscle Contraction
- Original Research
Details 詳細情報について
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- CRID
- 1360565169515750400
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- ISSN
- 2051817X
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- PubMed
- 28408640
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE