Development of Nano-Carbon Biosensors Using Glycan for Host Range Detection of Influenza Virus

DOI Web Site 被引用文献4件 参考文献56件 オープンアクセス
  • Toshio Kawahara
    College of Engineering, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
  • Hiroaki Hiramatsu
    College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
  • Yasuo Suzuki
    College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan
  • Shin-ichi Nakakita
    Life Science Research Center, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
  • Yasuhide Ohno
    Graduate School of Science and Technology, Tokushima University, 2-24 Shinkura-cho, Tokushima 770-8501, Japan
  • Kenzo Maehashi
    Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan
  • Kazuhiko Matsumoto
    The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Osaka 567-0047, Japan
  • Kazumasa Okamoto
    Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan
  • Teruaki Matsuba
    Nissin Electric Co. Ltd., 47 Umezu-Takase-cho, Ukyo-ku, Kyoto 615-8686, Japan
  • Risa Utsunomiya
    Nissin Electric Co. Ltd., 47 Umezu-Takase-cho, Ukyo-ku, Kyoto 615-8686, Japan

説明

<jats:p>Nano-carbon materials are promising canidates for applications in high performance devices, including highly sensitive biosensors. We have developed a self-alignment process for nano-carbon field effect transistors (FETs), using a carbon nanowall (CNW)—a nano-carbon materials—to fabricate CNW-FETs. We measured the pH dependence of the device properties. The binding molecules are known to be key components for biosensors. We are concentrating on the development of an influenza virus sensor, because the influenza virus is a major public health problem and a highly sensitive sensor is urgently required. We estimated the size of detected molecules of glycan for influenza viruses using atomic force microscopy. The typical molecule size is around 1 nm, and this may be suitable for electronic detection using a FET structure.</jats:p>

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