Protective Effect of Chitin Urocanate Nanofibers against Ultraviolet Radiation

DOI Web Site PubMed 参考文献31件 オープンアクセス
  • Ikuko Ito
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Toshikazu Yoneda
    Omura Toryo Co., Ltd., 87, 3-Chome, Chiyomi, Tottori 680-0991, Japan
  • Yoshihiko Omura
    Omura Toryo Co., Ltd., 87, 3-Chome, Chiyomi, Tottori 680-0991, Japan
  • Tomohiro Osaki
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Shinsuke Ifuku
    Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
  • Hiroyuki Saimoto
    Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
  • Kazuo Azuma
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Tomohiro Imagawa
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Takeshi Tsuka
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Yusuke Murahata
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Norihiko Ito
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Yoshiharu Okamoto
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan
  • Saburo Minami
    Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8553, Japan

書誌事項

公開日
2015-12-19
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.3390/md13127076
公開者
MDPI AG

説明

<jats:p>Urocanic acid is a major ultraviolet (UV)-absorbing chromophore. Chitins are highly crystalline structures that are found predominantly in crustacean shells. Alpha-chitin consists of microfibers that contain nanofibrils embedded in a protein matrix. Acid hydrolysis is a common method used to prepare chitin nanofibrils (NFs). We typically obtain NFs by hydrolyzing chitin with acetic acid. However, in the present study, we used urocanic acid to prepare urocanic acid chitin NFs (UNFs) and examined its protective effect against UVB radiation. Hos: HR-1 mice coated with UNFs were UVB irradiated (302 nm, 150 mJ/cm2), and these mice showed markedly lower UVB radiation-induced cutaneous erythema than the control. Additionally, sunburn cells were rarely detected in the epidermis of UNFs-coated mice after UVB irradiation. Although the difference was not as significant as UNFs, the number of sunburn cells in mice treated with acetic acid chitin nanofibrils (ANFs) tended to be lower than in control mice. These results demonstrate that ANFs have a protective effect against UVB and suggest that the anti-inflammatory and antioxidant effects of NFs influence the protective effect of ANFs against UVB radiation. The combination of NFs with other substances that possess UV-protective effects, such as urocanic acid, may provide an enhanced protective effect against UVB radiation.</jats:p>

収録刊行物

  • Marine Drugs

    Marine Drugs 13 (12), 7463-7475, 2015-12-19

    MDPI AG

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