Catalytic C−H/C−F Coupling of Azoles and Acyl Fluorides
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- Yohei Ogiwara
- Department of Pure and Applied Chemistry Faculty of Science and Technology Tokyo University of Science Noda Chiba 2 78-8510 Japan
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- Yurika Iino
- Department of Pure and Applied Chemistry Faculty of Science and Technology Tokyo University of Science Noda Chiba 2 78-8510 Japan
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- Norio Sakai
- Department of Pure and Applied Chemistry Faculty of Science and Technology Tokyo University of Science Noda Chiba 2 78-8510 Japan
Abstract
<jats:title>Abstract</jats:title><jats:p>A method for the palladium/copper‐catalyzed direct acylation of azoles with acyl fluorides is described. This study reports the first examples of acyl fluorides being used as acylation reagents in transition‐metal‐catalyzed aromatic C−H bond functionalization reactions. Depending on the reaction temperature, decarbonylative coupling may also occur. Mechanistic studies suggest that the cleavage of the aromatic C−H bond, promoted by a copper‐phosphine species, is not the rate‐limiting step of this acylation.</jats:p>
Journal
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- Chemistry – A European Journal
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Chemistry – A European Journal 25 (26), 6513-6516, 2019-04-17
Wiley
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Details 詳細情報について
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- CRID
- 1360567179950583936
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- ISSN
- 15213765
- 09476539
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- Data Source
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- Crossref
- KAKEN