Modified triexponential analysis of intravoxel incoherent motion for brain perfusion and diffusion

DOI DOI Web Site Web Site 被引用文献9件 参考文献25件
  • Naoki Ohno
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences; Kanazawa University; Kanazawa Japan
  • Tosiaki Miyati
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences; Kanazawa University; Kanazawa Japan
  • Satoshi Kobayashi
    Department of Radiology; Kanazawa University Hospital; Kanazawa Japan
  • Toshifumi Gabata
    Department of Radiology; Kanazawa University Hospital; Kanazawa Japan

書誌事項

タイトル別名
  • Modified Triexponential Analysis of IVIM for Brain Perfusion and Diffusion

説明

Background To noninvasively obtain more detailed information on brain perfusion and diffusion using modified triexponential analysis. Methods On a 3.0 Tesla MRI, diffusion-weighted imaging of the brain with multiple b-values was performed in healthy volunteers (n = 12). We derived perfusion-related, fast-free, and slow-restricted diffusion coefficients (Dp, Df, and Ds, respectively) and fractions (Fp, Ff, and Fs, respectively) in the frontal and occipital white matter, caudate nucleus, and putamen calculated from triexponential function by a two-step approach. Ds was initially determined using monoexponential function in b-values over 1000 s/mm2 and was applied to triexponential function. Additionally, the literature value of the diffusion coefficient of free water at 37 °C was assigned to Df. Finally, Dp and fractions were derived using all b-values. Moreover, biexponential analysis was performed and compared with triexponential analysis. We also determined regional cerebral blood flow (rCBF) using arterial spin labeling and assessed its relation with each diffusion parameter. Results Significant positive correlations between Dp and rCBF were found in the caudate nucleus (R = 0.84; P = 0.01) and putamen (R = 0.86; P = 0.01), whereas no diffusion parameters were significantly correlated with rCBF on biexponential analysis (P > 0.05 for all). Conclusion Diffusion analysis with triexponential function enables noninvasive gathering of more detailed information on brain perfusion and diffusion. J. Magn. Reson. Imaging 2015.

収録刊行物

被引用文献 (9)*注記

もっと見る

参考文献 (25)*注記

もっと見る

関連プロジェクト

もっと見る

問題の指摘

ページトップへ