Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination

  • Hirohisa Watanabe
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Jo Senda
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Shigenori Kato
    Department of Neurology Ichinomiya Municipal Hospital Ichinomiya Japan
  • Mizuki Ito
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Naoki Atsuta
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Kazuhiro Hara
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Takashi Tsuboi
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Masahisa Katsuno
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Tomohiko Nakamura
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Masaaki Hirayama
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Hiroaki Adachi
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
  • Shinji Naganawa
    Department of Radiology Nagoya University Graduate School of Medicine Nagoya Japan
  • Gen Sobue
    Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan

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<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used 3T magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD‐VH; n = 13) and PD patients without VH (PD‐C; n = 13).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The PD‐VH patients showed significant cortical atrophy compared to the PD‐C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>VH in PD can occur due to distinctive neuroanatomical involvement. © 2013 International Parkinson and Movement Disorder Society</jats:p></jats:sec>

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