Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination
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- Hirohisa Watanabe
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Jo Senda
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Shigenori Kato
- Department of Neurology Ichinomiya Municipal Hospital Ichinomiya Japan
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- Mizuki Ito
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Naoki Atsuta
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Kazuhiro Hara
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Takashi Tsuboi
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Masahisa Katsuno
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Tomohiko Nakamura
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Masaaki Hirayama
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Hiroaki Adachi
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
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- Shinji Naganawa
- Department of Radiology Nagoya University Graduate School of Medicine Nagoya Japan
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- Gen Sobue
- Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan
抄録
<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We used 3T magnetic resonance imaging (MRI) and voxel‐based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD‐VH; n = 13) and PD patients without VH (PD‐C; n = 13).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The PD‐VH patients showed significant cortical atrophy compared to the PD‐C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>VH in PD can occur due to distinctive neuroanatomical involvement. © 2013 International Parkinson and Movement Disorder Society</jats:p></jats:sec>
収録刊行物
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- Movement Disorders
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Movement Disorders 28 (12), 1732-1736, 2013-10
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360567180175465344
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- ISSN
- 15318257
- 08853185
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- データソース種別
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- Crossref
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