Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers
-
- Kiyoshi Masuda
- Kawasaki Medical School at Kurashiki‐City Okayama Japan
-
- Yuki Kuwano
- Department of Pathophysiology, Institute of Biomedical Sciences Tokushima University Graduate School at Tokushima‐City Tokushima Japan
抄録
<jats:p>Gene expression patterns in cancer cells are strongly influenced by posttranscriptional mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene regulation; they can interact with target mRNAs in a sequence‐ and structure‐dependent manner, and determine cellular behavior by manipulating the processing of these mRNAs. Numerous RBPs are aberrantly deregulated in many human cancers and hence, affect the functioning of mRNAs that encode proteins, implicated in carcinogenesis. Here, we summarize the key roles of RBPs in posttranscriptional gene regulation, describe RBPs disrupted in cancer, and lastly focus on RBPs that are responsible for implementing cancer traits in the digestive tract. These evidences may reveal a potential link between changes in expression/function of RBPs and malignant transformation, and a framework for new insights and potential therapeutic applications.</jats:p><jats:p>This article is categorized under:<jats:list list-type="simple"> <jats:list-item><jats:p>RNA in Disease and Development > RNA in Disease</jats:p></jats:list-item> <jats:list-item><jats:p>RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications</jats:p></jats:list-item> </jats:list> </jats:p>
収録刊行物
-
- WIREs RNA
-
WIREs RNA 10 (3), 2018-11-26
Wiley
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1360567180273114752
-
- ISSN
- 17577012
- 17577004
-
- データソース種別
-
- Crossref
- KAKEN