Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim, Kyung-Chul Yoon, Kyoung Yul Seo, Choun-Ki Joo, Virender Sangwan, Varsha Rathi, Sayan Basu, Almas Shamaila, Hyo Seok Lee, Sangchul Yoon, Chie Sotozono, José Álvaro Pereira Gomes, Katsushi Tokunaga, Shigeru Kinoshita

doi:10.1038/srep05981

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.

Trans-ethnic study confirmed independent associations of HLA-A02:06 and HLA-B44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

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