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- Maki Minakawa
- Department of Applied Chemistry, Chemical Engineering and Biochemical Engineering, Yamagata University
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- Kouichi Watanabe
- Department of Chemistry, College of Humanities & Science, Nihon University
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- Satoru Toyoda
- Department of Applied Chemistry, Chemical Engineering and Biochemical Engineering, Yamagata University
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- Yasuhiro Uozumi
- Institute for Molecular Science
説明
<jats:p>We developed an environmentally friendly iridium-catalyzed direct cyclization of aromatic amines with diols that generates the corresponding N-heterocyclic compounds with water as the sole by-product. Thus, under conditions of 165 °C for 18 hours, the direct cyclization of N-methylanilines with 1,3-propanediol by using an IrCl3 catalyst with rac-BINAP as a ligand in mesitylene afforded the corresponding tetrahydroquinoline derivatives with yields ranging from 73 to 83%. Under similar reaction conditions, direct cyclization of anilines with 1,3-propanediol produced the corresponding tetrahydrobenzoquinolizine derivatives with yields ranging from 26 to 76%.</jats:p>
収録刊行物
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- Synlett
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Synlett 29 (18), 2385-2389, 2018-10-02
Georg Thieme Verlag KG
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詳細情報 詳細情報について
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- CRID
- 1360567183733445632
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- ISSN
- 14372096
- 09365214
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- データソース種別
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- Crossref
- KAKEN